E7820 | RBM39 molecular glue
CAS:
289483-69-8
Catalog Number:
10-3935
Cancer
Cancer is a collection of related genetic diseases that cause cells to divide uncontrollably and spread to surrounding tissues. Phenotypic changes to cancer cells include abnormal shape, fast rate of division, high metabolic rate, and invasion of surrounding tissues. The aberrant genes that lead to cancer can arise from DNA damage caused by environmental sources, errors that occur during cell division, or inherited. Tumor promoting genetic mutations occur in oncogenes that activate pathways related to cell proliferation or inactivate cell death pathways. Mutations in tumor suppressor genes lead to loss of function in growth inhibition, DNA damage repair, and apoptosis activation pathways.
ADC warheads
Angiogenesis
ABT-869 | Dual VEGFR and PDGFR kinase inhibitor
CAS:
796967-16-3
Catalog Number:
10-5268
Vandetanib | VEGFR2 inhibitor
CAS:
443913-73-3
Catalog Number:
10-2185
Activity:
VEGFR2 inhibitor
Chemical Names:
4-(4-Bromo-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-4-yl)methoxy]quinazoline
Alternate Name:
ZD6474
Molecular Weight:
475.35
Molecular Formula:
C22H24BrFN4O2
Solubility:
Soluble in DMSO (30 mg/ml); Ethanol (10 mg/ml with warming)
Physical Properties:
White to off-white solid
Purity:
98% TLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT
Autophagy
PF-543 HCl | Sphingosine kinase-1 inhibitor
CAS:
1706522-79-3
Catalog Number:
10-4998
Vacuolin-1 | Autophagy/PIKfyve inhibitor
CAS:
351986-85-1
Catalog Number:
10-5151
Verteporfen | YAP Inhibitor
CAS:
129497-78-5
Catalog Number:
10-3487
Activity:
YAP inhibitor
Chemical Name:
(4R,4aS)-18-Ethenyl-4,4a-dihydro-3,4-bis(methoxycarbonyl)-4a,8,14,19-tetramethyl-24H,26H-benzo[b]porphine-9,13-dipropanoic acid monomethyl ester
Alternate Names:
CL 318952; BPD-MA
Molecular Weight:
718.79
Molecular Formula:
C41H42N4O8
Solubility:
Soluble in DMSO (up to 14 mg/ml)
Physical Properties:
Black solid
Purity:
98% by TLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchsae as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Cancer cell metabolism
MitoBloCK-10 | TIMM44 blocker
CAS:
394694-98-5
Catalog Number:
10-5324
EV-96 | Cysteine-reactive T cell activation suppressor
CAS:
N/A
Catalog Number:
10-3949
E7820 | RBM39 molecular glue
CAS:
289483-69-8
Catalog Number:
10-3935
Cancer Stem Cells
STF-118804 | NAMPT inhibitor
CAS:
894187-61-2
Catalog Number:
10-5640
CBL0137 | Inhibitor of the histone chaperone FACT
CAS:
1197996-80-7
Catalog Number:
10-4026
Sulconazole | Antifungal/ Prevents cancer stem cell formation
CAS:
61318-91-0
Catalog Number:
10-3955
Activity:
Antifungal/Prevents cancer stem cell formation
Chemical Names:
1-[2-[(4-Chlorophenyl)methylsulfanyl]-2-(2,4-dichlorophenyl)ethyl]imidazole nitrate
Molecular Weight:
460.75
Molecular Formula:
C18H15Cl3N2S·HNO3
Solubility:
Soluble in DMSO (up to 25 mg/ml)
Physical Properties:
White solid
Purity:
>98% TLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT
Cell Cycle
WM-1119 | HAT KAT6A inhibitor
CAS:
2055397-28-7
Catalog Number:
10-4013
SU9516 | pan-specific CDK inhibitor
CAS:
SU9516
Catalog Number:
10-5705
Activity:
pan-specific CDK inhibitor
Chemical Names:
(Z)-1,3-Dihydro-3-(1H-imidazol-4-ylmethylene)-5-methoxy-2H-2-one
Molecular Weight:
241.25
Molecular Formula:
C13H11N3O2
Solubility:
Soluble in DMSO (25 mg/ml)
Physical Properties:
Orange solid
Purity:
>98% HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT
NG52 | Phosphoglycerate kinase 1 inhibitor
CAS:
212779-48-1
Catalog Number:
10-4681
Activity:
Phosphoglycerate kinase 1 inhibitor
Chemical Names:
2-[[6-(3-Chloroanilino)-9-propan-2-ylpurin-2-yl]amino]ethanol
Molecular Weight:
346.82
Molecular Formula:
C16H19ClN6O
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
Off-white solid
Purity:
>98% HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Cellular Stress
MitoBloCK-10 | TIMM44 blocker
CAS:
394694-98-5
Catalog Number:
10-5324
Honokiol-DCA | TRAP1 Inhibitor
CAS:
1620160-42-0
Catalog Number:
10-3596
Luminespib | HSP90 inhibitor
CAS:
747412-49-3
Catalog Number:
10-4672
Activity:
HSP90 inhibitor
Chemical Names:
5-(2,4-Dihydroxy-5-propan-2-ylphenyl)-N-ethyl-4-[4-(morpholin-4-ylmethyl)phenyl]-1,2-oxazole-3-carboxamide
Alternate Name:
NVP-AUY922; VER-52296
Molecular Weight:
465.54
Molecular Formula:
C26H31N3O5
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
White solid
Purity:
99% HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT
Chemotherapeutics
Selpercatinib | Potent and selective RET kinase inhibitor
CAS:
2152628-33-4
Catalog Number:
10-4407
Raltitrexed | Thymidylate synthase inhibitor
CAS:
112887-68-0
Catalog Number:
10-4052
MRTX849 | Covalent KRASG12C Inhibitor
CAS:
2326521-71-3
Catalog Number:
10-4985
Cytoskeleton
Dynarrestin | Cytoplasmic dynein 1/2 inhibitor
CAS:
2222768-84-3
Catalog Number:
10-4196
Cytochalasin B | Actin filament disrupting agent
CAS:
14930-96-2
Catalog Number:
10-2069
Activity:
Actin filament disrupting agent
Fermentation product:
from Drechslera dematioidea
Alternate Name:
NSC107658; Phominone
Molecular Weight:
479.61
Molecular Formula:
C29H37NO5
Solubility:
Soluble in DMSO (up to 5 mg/ml); Ethanol (10 mg/ml)
Physical Properties:
White solid
Purity:
98% HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT
Buparlisib | PI3-kinase inhibitor
CAS:
944396-07-0
Catalog Number:
10-4325
Activity:
pan-Class I PI3-kinase inhibitor
Chemical Names:
5-(2,6-Dimorpholin-4-ylpyrimidin-4-yl)-4-(trifluoromethyl)pyridine-2-amine; NVP-BKM120
Molecular Weight:
410.39
Molecular Formula:
C18H21F3N6O2
Solubility:
Soluble in DMSO (15 mg/ml)
Physical Properties:
White solid
Purity:
99% HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
DNA Damage/Repair
AOH1996 | PCNA inhibitor
CAS:
2089314-64-5
Catalog Number:
10-4992
TH10785 | OGG1 activator
CAS:
1002801-51-5
Catalog Number:
10-5698
Ochratoxin A | Mycotoxin
CAS:
303-47-9
Catalog Number:
10-3562
Drug resistance
JNK-IN-8 | Covalent JNK inhibitor
CAS:
1410880-22-6
Catalog Number:
10-4780
S07-2010 | pan-AKR1C inhibitor
CAS:
1223194-71-5
Catalog Number:
10-4148
IACS-010759 | Mitochondrial Complex I Inhibitor
CAS:
1570496-34-2
Catalog Number:
10-4475
Epigenetics
iPHF8 | Inhibitor of lysine demethylase PHF8
CAS:
N/A
Catalog Number:
10-4049
BRM014 | BRM/BRG1 ATPase inhibitor
CAS:
2270879-17-7
Catalog Number:
10-5244
WM-1119 | HAT KAT6A inhibitor
CAS:
2055397-28-7
Catalog Number:
10-4013
Gene Regulation/Transcription
HC-258 | Covalent TEAD inhibitor
CAS:
N/A
Catalog Number:
10-3931
BRM014 | BRM/BRG1 ATPase inhibitor
CAS:
2270879-17-7
Catalog Number:
10-5244
AOH1996 | PCNA inhibitor
CAS:
2089314-64-5
Catalog Number:
10-4992
Growth factors
Nintedanib | VEGFR, PDGFR, and FGFR kinase inhibitor
CAS:
656247-17-5
Catalog Number:
10-3320
Pazopanib | Multi-receptor tyrosine kinase inhibitor
CAS:
444731-52-6
Catalog Number:
10-2158
MRTX849 | Covalent KRASG12C Inhibitor
CAS:
2326521-71-3
Catalog Number:
10-4985
Immuno-oncology
LDC1267 | Inhibitor of TAM kinases
CAS:
1361030-48-9
Catalog Number:
10-4420
JH-X-119-01 | Selective IRAK1 inhibitor
CAS:
2227368-54-7
Catalog Number:
10-4691
Dubermatinib | AXL inhibitor
CAS:
1341200-45-0
Catalog Number:
10-4679
Kinases
JNK-IN-8 | Covalent JNK inhibitor
CAS:
1410880-22-6
Catalog Number:
10-4780
GSK2636771 | Potent and selective inhibitor of PI3Kß
CAS:
1372540-25-4
Catalog Number:
10-4172
LDC1267 | Inhibitor of TAM kinases
CAS:
1361030-48-9
Catalog Number:
10-4420
Metastasis
Decoyinine | Inhibitor of GMP synthase
CAS:
2004-04-8
Catalog Number:
10-5149
P053 | Protein phosphatase 5 inhibitor
CAS:
1022417-69-1
Catalog Number:
10-4060
C-DIM 8 | Nur77 Antagonist
CAS:
151358-47-3
Catalog Number:
10-5157
Activity:
Nur77 antagonist
Chemical Names:
1,1-Bis(3’-indolyl)-1-(p-hydroxyphenyl)methane
Alternate Name:
DIM-C-pPhOH
Molecular Weight:
338.41
Molecular Formula:
C23H18N2O
Solubility:
Soluble in DMSO (35 mg/ml); ethanol (35 mg/ml)
Physical Properties:
Pink solid
Purity:
>98% TLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT
p53 and other tumor suppressors
SR1078 | ROR agonist
CAS:
1246525-60-9
Catalog Number:
10-4066
Phenylhexyl isothiocyanate | Chemopreventive; HDAC inhibitor; p53 reactivator
CAS:
133920-06-6
Catalog Number:
10-5258
CBL0137 | Inhibitor of the histone chaperone FACT
CAS:
1197996-80-7
Catalog Number:
10-4026
Programmed cell death
7-Dehydrocholesterol | Ferroptosis inhibitor
CAS:
434-16-2
Catalog Number:
10-3941
P053 | Protein phosphatase 5 inhibitor
CAS:
1022417-69-1
Catalog Number:
10-4060
Phenylhexyl isothiocyanate | Chemopreventive; HDAC inhibitor; p53 reactivator
CAS:
133920-06-6
Catalog Number:
10-5258
Ubiquitin proteasome
E7820 | RBM39 molecular glue
CAS:
289483-69-8
Catalog Number:
10-3935
EN450 | NFkB1 molecular glue
CAS:
793719-01-4
Catalog Number:
10-3936
SJ6986 | GSPT1 molecular glue
CAS:
2765625-93-0
Catalog Number:
10-3933
Other Cancer
MitoBloCK-10 | TIMM44 blocker
CAS:
394694-98-5
Catalog Number:
10-5324
Lomitapide | Microsomal triglyceride transfer protein inhibitor
CAS:
182431-12-5
Catalog Number:
10-4664
Decoyinine | Inhibitor of GMP synthase
CAS:
2004-04-8
Catalog Number:
10-5149
