GSK620 | BD2 selective BET inhibitor
CAS:
2088410-46-0
Catalog Number:
10-4180
Epigenetics
Covalent modifications to DNA or histone proteins with various chemical groups can determine whether genes are turned on or off and can thus influence the production of proteins in a cell. This genetic control without altering DNA sequences is crucial in many normal cellular functions. Aberrant epigenetic alterations are present in myriad disease states. Pharmacological manipulation of the various enzymes involved in epigenetic changes in pathological states is an important new target in drug discovery. Writers (methyl and acetyl transferases) are enzymes capable of modifying nucleotide bases and amino acid residues on histones. Erasers (demethylases and deacetylases) remove these same modifications. Readers (bromodomains) are enzymes capable of recognizing specific epigenetic marks that direct a particular transcriptional outcome.
Bromodomains
CPI203 | BET bromodomain inhibitor
CAS:
1446144-04-2
Catalog Number:
10-4048
BI 9564 | BRD9 bromodomain inhibitor
CAS:
1883429-22-8
Catalog Number:
10-4320
Deubiquitinase
OTUDin3 | OTUD3 inhibitor
CAS:
441290-65-9
Catalog Number:
10-4981
Thiolutin | Inhibitor of the DUB PSMD14
CAS: 87-11-6
Catalog Number:
10-2106
Activity:
Inhibitor of the DUB PSMD14
Chemical Names:
N-(4,5-Dihydro-4-methyl-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl)acetamide;
Acetopyrrothin
Acetopyrrothin
Molecular Weight:
228.29
Molecular Formula:
C8H8N2O2S2
Solubility:
Soluble in DMSO (up to 15 mg/ml)
Physical Properties:
Yellow solid
Purity:
>98% HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 3 years as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
DNA methylation
DBIC | DNMT3B S-nitrosylation inhibitor
CAS:
487026-67-5
Catalog Number:
10-5161
DBIC-neg2 | DBIC negative control
CAS:
N/A
Catalog Number:
10-5162
Activity:
DBIC negative control
Chemical Names:
(E)-N’-(3,4-Dihydroxybenzylidene)acetohydrazide
Molecular Weight:
194.19
Molecular Formula:
C9H10N2O3
Solubility:
Soluble in DMSO (40 mg/ml)
Physical Properties:
Pale yellow solid
Purity:
>98% TLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT
SGI-1027 | DNA methyl transferase inhibitor
CAS:
1020149-73-8
Catalog Number:
10-5488
Activity:
DNA methyl transferase inhibitor
Chemical Names:
N-[4-[(2-Amino-6-methyl-4-pyrimidinyl)amino]phenyl]-4-(4-quinolinylamino)benzamide
Molecular Weight:
461.52
Molecular Formula:
C27H23N7O
Solubility:
Soluble in DMSO (up to 35 mg/ml)
Physical Properties:
Off-white solid
Purity:
98% TLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
DNA demethylation
TETi76 ester | TET inhibitor
CAS:
1451750-73-4
Catalog Number:
10-4041
Histone acetylation
WM-1119 | HAT KAT6A inhibitor
CAS:
2055397-28-7
Catalog Number:
10-4013
TTK21 | CBP/p300 histone acetyltransferase activator
CAS:
709676-56-2
Catalog Number:
10-5669
Activity:
Histone acetyltransferase CBP/p300 activator
Chemical Names:
N-[4-Chloro-3-(trifluoromethyl)phenyl]-2-propoxybenzamide
Molecular Weight:
357.76
Molecular Formula:
C17H15ClF3NO2
Solubility:
Soluble in DMSO (50 mg/ml)
Physical Properties:
Off-white solid
Purity:
>98% HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT
Acetyl-Coenzyme A 3Li | Acetylation and fatty acid biosynthesis cofactor
CAS:
75520-41-1
Catalog Number:
10-5384
Activity:
Cofactor for cellular metabolism/Acetyl donor
Chemical Name:
Acetyl-CoA
Molecular Weight:
881.42
Molecular Formula:
C23H35Li3N7O17P3S·3H2O
Solubility:
Soluble in water (10 mg/ml)
Physical Properties:
White solid
Purity:
90% (enzymatic)
Storage Temperature:
-20°C
Stability:
Stable for 2 years as supplied. Solutions in water may be stored at -20°C for up to 2 weeks.
Shipping Code:
RT
Histone deacetylation
Phenylhexyl isothiocyanate | Chemopreventive; HDAC inhibitor; p53 reactivator
CAS:
133920-06-6
Catalog Number:
10-5258
BG45 | HDAC3 selective inhibitor
CAS:
926259-99-6
Catalog Number:
10-5638
OSS-128167 | SIRT6 Inhibitor
CAS:
887686-02-4
Catalog Number:
10-5197
Activity:
SIRT6 inhibitor
Chemical Names:
5-(3-(Furan-2-carboxamido)benzamido)-2-hydroxybenzoic acid
Molecular Weight:
366.33
Molecular Formula:
C19H14N2O6
Solubility:
Soluble in DMSO (25 mg/ml); Ethanol (25 mg/ml)
Physical Properties:
Off-white solid
Purity:
>98% HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT
Histone demethylation
iPHF8 | Inhibitor of lysine demethylase PHF8
CAS:
N/A
Catalog Number:
10-4049
iJMJD6 | Arginine demethylase JMJD6 inhibitor
CAS:
899548-78-8
Catalog Number:
10-4039
Deferasirox | Iron Chelator
CAS:
201530-41-8
Catalog Number:
10-4949
Activity:
Iron chelator
Chemical Names:
4-[3,5-bis(2-Hydroxyphenyl)-1,2,4-triazol-1-yl]benzoic acid
Alternate Name:
ICL670
Molecular Weight:
373.36
Molecular Formula:
C21H15N3O4
Solubility:
Soluble in DMSO (10 mg/ml)
Physical Properties:
Off-white to white solid
Purity:
>98% HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT
Histone methylation
UNC0224 | G9a histone methyl transferase inhibitor
CAS:
1197196-48-7
Catalog Number:
10-5216
GSK126 | EZH2 methyltransferase inhibitor
CAS:
1346574-57-9
Catalog Number:
10-3394
Activity:
EZH2 methyltransferase inhibitor
Chemical Names:
N-[(1,2-Dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-3-methyl-1-[(1S)-1-methylpropyl]-6-[6-(1-piperazinyl)-3-pyridinyl]-1H-indole-4-carboxamide
Molecular Weight:
526.69
Molecular Formula:
C31H38N6O2
Solubility:
Soluble in DMSO (16 mg/ml)
Physical Properties:
Cream solid
Purity:
>98% HPLC/TLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Intelliscreen™ Polycomb Repressive Complex Inhibitors Mini-Library
Catalog Number:
10-7320
Description:
6 inhibitors of the polycomb-group proteins.
Solubility:
DMSO
Supplied As:
DMSO solution @ 10mM
Storage Temperature:
-80°C
Stability:
Stable for up to 1 year when stored as supplied @ -80°C
Price:
$475.00
Histone phosphorylation
Other
BRM014 | BRM/BRG1 ATPase inhibitor
CAS:
2270879-17-7
Catalog Number:
10-5244
UZH2 | METTL3 inhibitor
CAS:
2756566-45-5
Catalog Number:
10-4849
SGC-iMLLT | MLLT1/3 YEATS domain inhibitor
CAS:
2255338-25-9
Catalog Number:
10-4046
Activity:
MLLT1/3 YEATS domain inhibitor
Chemical Names:
(S)-1-Methyl-N-(2-((2-methylpyrrolidin-1-yl)methyl)-1H-benzo[d]imidazole-5-yl)-1H-indazole-5-carboxamide
Molecular Weight:
388.48
Molecular Formula:
C22H24N6O
Solubility:
Soluble in DMSO (at least 50 mg/ml)
Physical Properties:
Off-white to beige solid
Purity:
>98% HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
