BiochemicalTargets

Mitochondria

Mitochondria are organelles found in every cell and provide most of the energy for cellular functioning and survival. They also help regulate cellular metabolism, are involved in apoptosis, calcium signaling, cell cycle control, and cell growth and differentiation. Mitochondrial dysfunction has been implicated in metabolic disorders, neurodegenerative diseases, ischemia-related heart and brain injury, cancer, cardiovascular disease, and other disorders.

Glutathione

2-AAPA | Glutathione/thioredoxin reductase inhibitor

CAS:
1133387-90-2
Catalog Number:
10-3238
Activity:
Glutathione/thioredoxin reductase inhibitor
Chemical Names:
R,R′-2-Acetylamino-3-[4-(2-acetylamino-2-carboxyethylsulfanylthiocarbonylamino)-phenylthiocarbamoylsulfanyl]propionic acid, hydrate
Molecular Weight:
518.65
Molecular Formula:
C18H22N4O6S4
Solubility:
Soluble in DMSO (50 mg/ml)
Physical Properties:
White to off-white solid
Purity:
95% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month1.
Shipping Code:
RT

Dehydrozingerone | Glutathione sponge

CAS:
1080-12-2
Catalog Number:
10-2526
Activity:
Glutathione sponge
Chemical Name:
(E)-4-(4-Hydroxy-3-methoxyphenyl)but-3-ene-2-one
Molecular Weight:
192.21
Molecular Formula:
C11H12O3
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml).
Physical Properties:
Pale yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Shipping Code:
RT

Carnosic acid | Antioxidant

CAS:
3650-09-7
Catalog Number:
10-2401
Activity:
antioxidant
Chemical Name:
Natural diterpenoid resorcinol isolated from Rosmarinus officinalis.
Molecular Weight:
332.42
Molecular Formula:
C20H28O4
Solubility:
Soluble in DMSO (up to 50 mg/ml).
Physical Properties:
Off-white or yellow solid
Purity:
95% by HPLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Shipping Code:
RT
VIEW ALL Glutathione PRODUCTS

Krebs Cycle

VIEW ALL Krebs Cycle PRODUCTS

Membrane permeability

Tropodithietic acid | Cytotoxic disulfide antibiotic

CAS:
750590-18-2
Catalog Number:
10-3307
Activity:
Cytotoxic disulfide antibiotic
Chemical Name:
Oxo-8,9-dithiabicyclo[5.2.0]non-1,4,6-triene-2-carboxylic acid
Molecular Weight:
212.25
Molecular Formula:
C8H4O3S2
Solubility:
Soluble in DMSO (up to 5 mg/ml)
Physical Properties:
Orange solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Cereulide | Mitochondrial toxin

CAS:
157232-64-9
Catalog Number:
10-2746
Activity:
Mitochondrial toxin
Source:
Isolated from Bacillus cereus
Molecular Weight:
1153.40
Molecular Formula:
C57H96N6O18
Solubility:
Soluble in DMSO or Ethanol
Supplier As:
Supplied in Methanol at a concentration of 25μg/500μl
Purity:
98% by HPLC
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Diluted solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Beauvericin | Disrupts mitochondrial volume

CAS:
26048-05-5
Catalog Number:
10-2061
Activity:
Disrupts mitochondrial volume
Chemical Names:
Cyclo[(2R)-2-hydroxy-3-methylbutanoyl-N-methyl-L-phenylalanyl-(2R)-2-hydroxy-3-methylbutanoyl-N-methyl-L-phenylalanyl-(2R)-2-hydroxy-3-methylbutanoyl-N-methyl-L-phenylalanyl]
Molecular Weight:
783.95
Molecular Formula:
C45H57N3O9
Solubility:
Soluble in DMSO (30 mg/ml)
Physical Properties:
White solid
Purity:
98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
VIEW ALL Membrane permeability​ PRODUCTS

Mitochondrial Transporters

Oligomycin A | Mitochondrial ATPase inhibitor

CAS:
579-13-5
Catalog Number:
10-5368
Activity:
Mitochondrial ATPase inhibitor
Source:
Streptomyces sp.
Molecular Weight:
791.06
Molecular Formula:
C45H74O11
Solubility:
Soluble in DMSO (up to 300 mg/ml); Ethanol (up to 200 mg/ml)
Physical Properties:
White solid
Purity:
>98% TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

MitoBloCK-12 | Mitochondrial import inhibitor

CAS:
522-51-0
Catalog Number:
10-1525
Activity:
Mitochondrial import inhibitor
Chemical Name:
1,1’-Decamethylenebis(4-aminoquinaldinium)dichloride
Alternate Name:
Dequalinium chloride; MB12; DECA
Molecular Weight:
527.58
Molecular Formula:
C30H40Cl2N4
Solubility:
Soluble in DMSO (up to 1 mg/ml with warming) or in Water (up to 1 mg/ml)
Physical Properties:
Beige solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
Shipping Code:
RT
VIEW ALL Mitochondrial Transporters PRODUCTS

Oxidative Phosphorylation /
Respiratory chain

VIEW ALL Oxidative Phosphorylation /
Respiratory chain​ PRODUCTS

ROS

VIEW ALL ROS PRODUCTS

Targeted Reagents

VIEW ALL Targeted Reagents​ PRODUCTS

Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21

Focus Biomolecules
Plymouth Meeting, PA USA
1-855-FOCUS21

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