The Wnt/ß-catenin pathway is a multi-component pathway primarily involved in embryonic development, adult tissue homeostasis, and cell proliferation. Wnt proteins (i.e Wnt1, Wnt3a, Wnt5a) mediate extracellular signals that activate Wnt membrane receptors Frizzled and LRP5/6. Once activated, these signals inactivate a ß-catenin degradation complex allowing ß-catenin to translocate to the nucleus where it binds to TCF enabling target gene transcription
The Protein kinase C family of serine/threonine kinases is involved in many cellular processes including gene transcription, cell growth and proliferation, membrane structure, and various immune responses. The IntelliscreenTM Protein kinase C mini-library contains selective and pan-inhibitors of family.
Neuropathic pain is caused by damage or dysfunction to peripheral or central nervous system nerve fibers and is frequently chronic in nature. Persistent increased excitability and spontaneous activity in neurons leads to chronic pain that is difficult to treat.
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